| Cast 16 |
| Dafne Keen - Lyra Belacqua |
| Ruth Wilson - Marisa Coulter |
| Clarke Peters - Dr. Carne |
| James Cosmo - Farder Coram |
| Lin-Manuel Miranda - Lee Scoresby |
| Anne-Marie Duff - Ma Costa |
| Daniel Frogson - Tony Costa |
| Ariyon Bakare - Lord Carlo Boreal |
| Lucian Msamati - John Faa |
| Amir Wilson - Will Parry |
| Lewin Lloyd - Roger Parslow |
| Ruta Gedmintas - Serafina Pekkala |
| Gary Lewis - Thorold |
| Nina Sosanya - Elaine Parry |
| Lia Williams - Dr. Cooper |
| James McAvoy |
| Guest Stars 16 |
| Ruby Llewelyn - Rose |
| Mary Fernandez - Esme |
| Kate Rutter - Sister Betty |
| Raffiella Chapman - Annie Padian |
| Amit Shah - Dr. Rendal |
| Eva Jazani - Bridget McGinn |
| Amma Ris - Martha Fairwell |
| Martha Bright - Bella |
| Morfydd Clark - Sister Clara |
| Cristela Alonzo - Hester (voice) |
| Andrew Scott - Col. John Parry |
| Kit Connor - Pantalaimon (voice) |
| Robert Emms - Thomas |
| Eloise Little - Salcilia (voice) |
| Joe Tandberg - Iorek Byrnison (voice) |
| Jamie Wilkes - DI Walters |
| Production 15 |
| Carolyn Blackwood - Executive Producer |
| Toby Emmerich - Executive Producer |
| Deborah Forte - Executive Producer |
| Julie Gardner - Executive Producer |
| Philip Pullman - Executive Producer |
| Kathleen Crawford - Casting Director |
| Danny Jackson - Casting Director |
| Kathy Nettleship - Line Producer |
| Ryan Rasmussen - Executive Producer |
| Joel Collins - Executive Producer |
| Otto Bathurst - Executive Producer |
| Jack Thorne - Executive Producer |
| Dan McCulloch - Executive Producer |
| Ben Irving - Executive Producer |
| Jane Tranter - Executive Producer |
| Writing 1 |
| Philip Pullman - Book |
| Costume & Make-Up 1 |
| Caroline McCall - Costume Designer |
| Sound 1 |
| Lorne Balfe - Original Music Composer |
| Visual Effects 1 |
| Russell Dodgson - Visual Effects Supervisor |
| Art 1 |
| Joel Collins - Production Design |
| Network 1 |
| BBC One |
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