| Cast 15 |
| Wentworth Miller - Michael Scofield |
| Marshall Allman - LJ Burrows |
| Dominic Purcell - Lincoln Burrows |
| Sarah Wayne Callies - Dr. Sara Tancredi |
| Paul Adelstein - Paul Kellerman |
| Rockmond Dunbar - Benjamin Miles "C-Note" Franklin |
| Muse Watson - Charles Westmoreland |
| Robert Knepper - Theodore "T-Bag" Bagwell |
| Amaury Nolasco - Fernando Sucre |
| Peter Stormare - John Abruzzi |
| Robin Tunney - Veronica Donovan |
| Wade Williams - Bradley "Brad" Bellick |
| Lane Garrison - David "Tweener" Apolskis |
| Silas Weir Mitchell - Charles "Haywire" Patoshik |
| Stacy Keach - Henry Pope |
| Guest Stars 9 |
| Jessalyn Gilsig - Lisa Burrows |
| Ora Jones - Wendy |
| Adina Porter - Leticia Barris |
| Tab Baker - Crab Simmons |
| Linara Washington - Jenae Conlin |
| Gianni Russo - Smallhouse |
| Al Sapienza - Philly Falzone |
| Anthony Starke - Sebastian |
| Danny McCarthy - Danny Hale |
| Production 8 |
| Nick Santora - Producer |
| Paul Scheuring - Producer |
| Matt Olmstead - Producer |
| Marty Adelstein - Producer |
| Brett Ratner - Producer |
| Kevin Hooks - Producer |
| Neal H. Moritz - Producer |
| Dawn Parouse - Producer |
| Network 1 |
| FOX |
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