| Bill Murray - Dr. Peter Venkman |
| Dan Aykroyd - Dr. Raymond Stantz |
| Sigourney Weaver - Dana Barrett |
| Harold Ramis - Dr. Egon Spengler |
| Rick Moranis - Louis Tully |
| Annie Potts - Janine Melnitz |
| William Atherton - Walter Peck |
| Ernie Hudson - Winston Zeddmore |
| David Margulies - Mayor |
| Jennifer Runyon - Female Student |
| Michael Ensign - Hotel Manager |
| Slavitza Jovan - Gozer |
| Steven Tash - Male Student |
| Alice Drummond - Librarian |
| Jordan Charney - Dean Yager |
| Timothy Carhart - Violinist |
| John Rothman - Library Administrator |
| Tom McDermott - Archbishop |
| John Ring - Fire Commissioner |
| Norman Matlock - Police Commissioner |
| Joe Cirillo - Police Captain |
| Joe Schmieg - Police Seargeant |
| Roger Grimsby - Himself |
| Larry King - Himself |
| Joe Franklin - Himself |
| Casey Kasem - Himself |
| Reginald VelJohnson - Jail Guard |
| Rhoda Gemignani - Real Estate Woman |
| Murray Rubin - Man at Elevator |
| Larry Dilg - Con Edison Man |
| Danny Stone - Coachman |
| Patty Dworkin - Woman at Party |
| Jean Kasem - Tall Woman at Party |
| Lenny Del Genio - Doorman |
| Frances E. Nealy - Chambermaid |
| Sam Moses - Hot Dog Vendor |
| Christopher Wynkoop - TV Reporter |
| Winston May - Businessman in Cab |
| Tommy Hollis - Mayor's Aide |
| Eda Reiss Merin - Louis's Neighbor |
| Ric Mancini - Policeman at Apartment |
| Carol Ann Henry - Reporter |
| James Hardie - Reporter |
| Frantz Turner - Reporter |
| Paul Trafas - Ted Fleming |
| Cheryl Birchenfield - Annette Fleming |
| Kymberly Herrin - Dream Ghost |
| Stanley Grover - Reporter |
| Ruth Oliver - Library Ghost |
| Nancy Kelly - Reporter |
