Tobey Maguire
- Peter Parker / Spider-Man |
Kirsten Dunst
- Mary Jane Watson |
James Franco
- Harry Osborn / New Goblin |
Thomas Haden Church
- Flint Marko / Sandman |
Topher Grace
- Eddie Brock / Venom |
Bryce Dallas Howard
- Gwen Stacy |
Dylan Baker
- Curt Connors |
Rosemary Harris
- May Parker |
J.K. Simmons
- J. Jonah Jameson |
James Cromwell
- Captain Stacey |
Theresa Russell
- Mrs. Marko |
Bill Nunn
- Joseph Robertson |
Bruce Campbell
- Maître D' |
Elizabeth Banks
- Miss Brant |
Ted Raimi
- Hoffman |
Perla Haney-Jardine
- Penny Marko |
Willem Dafoe
- Norman Osborn / Green Goblin |
Cliff Robertson
- Ben Parker |
Elya Baskin
- Mr. Ditkovitch |
Mageina Tovah
- Ursula |
John Paxton
- Houseman |
Becky Ann Baker
- Mrs. Stacy |
Stan Lee
- Man in Times Square |
Michael Papajohn
- Dennis Carradine / Carjacker |
Joe Manganiello
- Flash Thompson |
Hal Fishman
- Anchorman |
Lucy Gordon
- Jennifer Dugan |
Steve Valentine
- Photographer |
Tim Maculan
- Play Director |
Marc Vann
- Play Producer |
Joe Bays
- Jazz Club Manager |
Gregg Daniel
- Precinct Detective |
Rogelio T. Ramos
- Emergency Room Doctor |
Timothy Patrick Quill
- Crane Operator |
Christopher Young
- Pianist |
Grant Curtis
- Driver |
Toni Wynne
- Congratulatory Woman at Daily Bugle |
Andre B. Blake
- Crane Disaster Radio Policeman |
Kathryn Bryding
- Woman Outside Theater |
Joe Virzi
- Police Detective |
Bill E. Rogers
- New Jersey State Policeman |
Michael Alexander
- New Jersey State Policeman |
April Parker-Jones
- Test Site Technician |
Edward Padilla
- Test Site Technician |
Robert Curtis Brown
- Test Site Technician |
Paul Terrell Clayton
- Test Site Technician |
Carolyn Neff
- Test Site Technician |
Christina Cindrich
- Test Site Technician |
Sonya Maddox
- ICU Nurse |
Derrick 'Phoenix' Thomas
- Cop at Crane Disaster |
Jessi Collins
- Mary Jane's Replacement |
Michael McLaughlin
- Boy at Key to the City Ceremony |
Anne Gartlan
- Councilwoman |
Emilio Rivera
- Policeman at Sand Truck |
Keith Woulard
- Policeman at Sand Truck |
Reynaldo Gallegos
- Armored Car Driver |
Jim Coope
- Newstand Patron |
Dean Edwards
- Newstand Patron |
Margaret Laney
- Newstand Patron |
Aimee Miles
- Coffee Shop Waitress |
Tanya Bond
- Jazz Club Waitress |
Mark Kubr
- Jazz Club Bouncer |
Tony Besson
- Photoshoot Client |
Ramon Adams
- Businessman (uncredited) |
A.J. Adelman
- Theater Attendee (uncredited) |
Angelis Alexandris
- Pedestrian (uncredited) |
Dawn Marie Anderson
- I.C.U Nurse (uncredited) |
Frank Anello
- NYPD Officer (uncredited) |
Anya Avaeva
- Model (uncredited) |
David Backus
- Bucket Boy (uncredited) |
Tiffany L. Baker
- News Reporter (uncredited) |
Sujeilee Candele
- Rescued Girl (uncredited) |
Michael Ciesla
- Photographer (uncredited) |
Irina Costa
- Jazz Club Waitress (uncredited) |
John Crann
- Theater Patron (uncredited) |
Crystal Marie Denha
- Jazz Club Girl (uncredited) |
Amy V. Dewhurst
- Columbia Grad Student (uncredited) |
Paul Edney
- New York City Commuter / Driver (uncredited) |
Natalie Fabry
- Girl at Key Ceremony (uncredited) |
Keith Fausnaught
- Pedestrian (uncredited) |
Shaun Patrick Flynn
- Businessman (uncredited) |
Logan Fry
- Automobile Driver (uncredited) |
Kevin Fung
- Spectator (uncredited) |
Tony Galtieri
- News Spectator (uncredited) |
Chuck Gerena
- Funeral Limo Driver (uncredited) |
Brian Hopson
- News Reporter (uncredited) |
Claude Jay
- Cop (uncredited) |
Julie Jei
- Female New Yorker (uncredited) |
Andrew James Jones
- Jazz Club Bouncer (uncredited) |
Natalie Jones
- Girl at Key Ceremony (uncredited) |
Christopher Jude
- Student (uncredited) |
Brittany Krall
- ER Nurse (uncredited) |
Pierangeli Llinas
- Woman in Court (uncredited) |
Bernadette Lords
- British Publicist (uncredited) |
Sandrine Marlier
- Shocked Pedestrian (uncredited) |
Laura McDavid
- Journalist (uncredited) |
Natalie McNeil
- Girl Screaming in Camaro (uncredited) |
Daniel Mignault
- Kid in Times Square (uncredited) |
Martha Millan
- Oscorp Receptionist (uncredited) |
Michele-Nanette Miller
- Girl in Times Square (uncredited) |
Claudia Katz Minnick
- Robbie's Assistant (uncredited) |
Robert Myers
- Theatergoer (uncredited) |
Jen Oda
- Beautiful Girl (uncredited) |
Anjelia Pelay
- Beautiful Woman (uncredited) |
Nick Poltoranin
- Police Officer (uncredited) |
Vanessa Reseland
- Beautiful Woman (uncredited) |
La Rivers
- Beautiful Woman (uncredited) |
Bria Roberts
- Businesswoman (uncredited) |
Vanessa Ross
- Sandman Victim (uncredited) |
Brenna Roth
- Bad Girl (uncredited) |
Shade Rupe
- City Hall Cheerer (uncredited) |
Arick Salmea
- Guy with Ticket (uncredited) |
Eric Shackelford
- Jazz Club Beatnik (uncredited) |
Daniel Shafer
- Jazz Club Guest (uncredited) |
Abbey Skinner
- Café Girl (uncredited) |
Kristin Somo
- Jazz Club Patron (uncredited) |
Jennifer Sparks
- Jazz Club Waitress (uncredited) |
Christopher Stadulis
- Firefighter (uncredited) |
Arne Starr
- Broadway Audience Member (uncredited) |
Liam Stone
- Jazz Club Musician (uncredited) |
Tajna Tanovic
- Girl in Cab (uncredited) |
Aija Terauda
- Model (uncredited) |
Brigid Turner
- Hot Girl (uncredited) |
Evelyn Vaccaro
- Beautiful Woman (uncredited) |
Nick Vlassopoulos
- Bar Patron #5 (uncredited) |
Sincerely A. Ward
- Model (uncredited) |
Silq Webster
- Model (uncredited) |
Graig F. Weich
- Student (uncredited) |
Fredrick Weiss
- Restaurant Patron (uncredited) |
Jennifer Weston
- ER Nurse (uncredited) |
Trenton Willey
- City Hall Cheerer (uncredited) |
Ray Wineteer
- Spectator (uncredited) |
Emily Eckes
- Beautiful Woman (uncredited) |