Patrick Stewart
- Charles Xavier / Professor X |
Hugh Jackman
- Logan / Wolverine |
Ian McKellen
- Eric Lehnsherr / Magneto |
Halle Berry
- Ororo Munroe / Storm |
Famke Janssen
- Jean Grey / Pheonix |
James Marsden
- Scott Summers / Cyclops |
Anna Paquin
- Anna Marie / Rogue |
Rebecca Romijn
- Raven Darkholme / Mystique / Grace |
Brian Cox
- William Stryker |
Alan Cumming
- Kurt Wagner / Nightcrawler |
Bruce Davison
- Senator Kelly |
Aaron Stanford
- John Allerdyce / Pyro |
Shawn Ashmore
- Bobby Drake / Ice Man |
Kelly Hu
- Yuriko Oyama / Lady Deathstrike |
Katie Stuart
- Katherine "Kitty" Pryde / Shadowcat |
Kea Wong
- Jubilation Lee / Jubilee |
Cotter Smith
- President McKenna |
Chiara Zanni
- White House Tour Guide |
Jackie A. Greenbank
- President's Secretary |
Michael Soltis
- White House Checkpoint Agent |
Michael David Simms
- White House Agent (Lead Agent) |
David Fabrizio
- Oval Office Agent Fabrizio |
Roger Cross
- Oval Office Agent Cartwright |
Richard Bradshaw
- Special Ops Agent |
Bryce Hodgson
- Artie |
Glen Curtis
- Museum Teenager #1 |
Greg Rikaart
- Museum Teenager #2 |
Shauna Kain
- Theresa Rourke / Siryn |
Ty Olsson
- Mitchell Laurio |
Alfonso Quijada
- Federal Bldg. Cleaning Twin #1 |
Rene Quijada
- Federal Bldg. Cleaning Twin #2 |
Brad Loree
- Stryker at age 40 |
Sheri G. Feldman
- Augmentation Room Doctor |
Connor Widdows
- Jones |
Daniel Cudmore
- Piotr Rasputin / Colossus |
Peter Wingfield
- Stryker Soldier Lyman |
Charles Siegel
- Dr. Shaw |
Steve Bacic
- Dr. Hank McCoy |
Michael Reid MacKay
- Jason 143 |
Layke Anderson
- Douglas Ramsey / Cypher |
Michael Dougherty
- Surgeon |
Dan Harris
- Surgeon |
James Kirk
- Ronny Drake |
Jill Teed
- Madeline Drake |
Alf Humphreys
- William Drake |
Michasha Armstrong
- Plastic Prison Guard |
Robert Hayley
- Cop |
Mark Lukyn
- Cop #1 (Lead Cop) |
Kendall Cross
- Cop #2 |
Keely Purvis
- Little Girl 143 |
Dylan Kussman
- Stryker Soldier Wilkins |
Jason S. Whitmer
- Stryker Soldier Smith |
Aaron Pearl
- Stryker Soldier |
Aaron Douglas
- Stryker Soldier |
Colin Lawrence
- Stryker Soldier |
Richard C. Burton
- Stryker Soldier |
Michael Joycelyn
- Stryker Soldier |
Nolan Gerard Funk
- X-Kid (captured) |
Devin Douglas Drewitz
- X-Kid (captured) |
Jermaine Lopez
- X-Kid (captured) |
Sideah Alladice
- X-Kid (captured) |
Kurt Max Runte
- Chief of Staff Abrahams |
Benjamin Glenday
- Cameraman |
Lori Stewart
- F-16 Fighter Pilot |
Ted Friend
- News Reporter |
Mi-Jung Lee
- News Reporter |
Marrett Green
- News Reporter |
Jill Krop
- News Reporter |
Brian Peck
- News Reporter |
Bryan Singer
- Prison Security Officer (uncredited) |