| Eddie Redmayne - Newt Scamander |
| Katherine Waterston - Porpentina "Tina" Goldstein |
| Alison Sudol - Queenie Goldstein |
| Johnny Depp - Gellert Grindelwald |
| Jude Law - Albus Dumbledore |
| Dan Fogler - Jacob Kowalski |
| Ezra Miller - Credence Barebone |
| Zoë Kravitz - Leta Lestrange |
| Callum Turner - Theseus Scamander |
| Claudia Kim - Nagini / The Maledictus |
| Carmen Ejogo - Seraphina Picquery |
| Jessica Williams - Eulalie Hicks |
| William Nadylam - Yusuf Kama |
| Ingvar Eggert Sigurðsson - Grimmson |
| Ólafur Darri Ólafsson - Skender |
| Kevin Guthrie - Abernathy |
| Brontis Jodorowsky - Nicolas Flamel |
| Derek Riddell - Torquil Travers |
| David Sakurai - Krall |
| Fiona Glascott - Minerva McGonagall |
| Wolf Roth - Spielman |
| Victoria Yeates - Bunty |
| Poppy Corby-Tuech - Vinda Rosier |
| Cornell John - Arnold Guzman |
| Sabine Crossen - Mrs. Lestrange |
| Claudius Peters - Nagel |
| Bart Soroczynski - Stebbins |
| Danielle Hugues - Irma Dugard |
| Alfie Simmons - McClaggan |
| Isaac Cortinovis Johnson - McClaggan's Friend |
| Olivia Popica - Receptionist |
| Alfie Mailley - Child in Bubble |
| Simon Wan - Auror Chang |
| Morrison Thomas - Old Carnie |
| Andrew Turner - MacDuff |
| Linda Santiago - Credence's Aunt |
| Alfrun Rose - Red Haired Young Witch |
| Maja Bloom - Carrow |
| Olwen Fouéré - Melusine |
| Simon Meacock - Krafft |
| David Wilmot - Portkey Trout |
| Ed Gaughan - French Policeman |
| Jamie Campbell Bower - Young Grindelwald |
| Toby Regbo - Young Dumbledore |
| Hugh Quarshie - Mustafa Kama |
| Isaura Barbé-Brown - Laurena Kama |
| Keith Chanter - Corvus Lestrange Senior |
| Jemima Woolnough - Gryffindor Girl |
| Hollie Burgess - Gryffindor Girl |
| Thea Lamb - Young Leta Lestrange (13-16 Years Old) |
| Joshua Shea - Young Newt (13-16 Years Old) |
| Isaac Domingos - Yusuf Kama (12 Years Old) |
| Ruby Woolfenden - Young Leta Lestrange (3-6 Years Old) |
| Johanna Thea - Ministry of Magic Witch (uncredited) |
| Liv Hansen - Ministry of Magic Witch (uncredited) |
| Israel Ruiz - Ministry of Magic Wizard (uncredited) |
| Jag Patel - Senior Wizard (uncredited) |
| Nick Owenford - Circus Wizard (uncredited) |
| Tahir Burhan - Wizard (uncredited) |
| Deepak Anand - Wizard (uncredited) |
| Alexandra Ford - Acolyte (uncredited) |
| Andrew Blackall - The Rowdy Frenchman (uncredited) |
| Christopher Birks - Young Auror-Auditorium (uncredited) |
| Phil Hodges - Prisoner 001 (uncredited) |
| Michael Haydon - Shopkeeper (uncredited) |
| Tim Ingall - Spectrum (uncredited) |
| Stephen McDade - Cirque Arcanus Worker (uncredited) |
| Jeremy Oliver - Circus passerby (uncredited) |
| Dave Simon - Muggle at Circus (uncredited) |
| Jason Redshaw - Chef (uncredited) |
| Callum Forman - Doorman (uncredited) |
| Ryan Hannaford - Sailor (uncredited) |
| Donna Preston - Circus Compare (uncredited) |
| Nasir Jama - Macusa Prison (uncredited) |
| Aykut Hilmi - Shafiq (uncredited) |
| Natalie Lauren - Parisian Woman (uncredited) |
| Annarie Boor - Wand Seller (uncredited) |
| Deano Bugatti - Muggle (uncredited) |
| Bernardo Santos - Muggle (uncredited) |
| Connor Wolf - Muggle (uncredited) |
| Sean Gislingham - Muggle (uncredited) |
| Adrian Wheeler - Party Guest (uncredited) |
| Sean Coleman - Teenager in House (uncredited) |
| Andy Summers - New Yorker (uncredited) |
