| Eddie Redmayne - Newt Scamander |
| Katherine Waterston - Porpentina "Tina" Goldstein |
| Alison Sudol - Queenie Goldstein |
| Dan Fogler - Jacob Kowalski |
| Jude Law - Albus Dumbledore |
| Ezra Miller - Credence Barebone |
| Johnny Depp - Gellert Grindelwald |
| Zoë Kravitz - Leta Lestrange |
| Callum Turner - Theseus Scamander |
| Claudia Kim - Nagini / The Maledictus |
| Carmen Ejogo - Seraphina Picquery |
| Jessica Williams - Eulalie Hicks |
| William Nadylam - Yusuf Kama |
| Ingvar Eggert Sigurðsson - Grimmson |
| Ólafur Darri Ólafsson - Skender |
| Kevin Guthrie - Abernathy |
| Brontis Jodorowsky - Nicolas Flamel |
| Tim Ingall - Spectrum (uncredited) |
| Deano Bugatti - Muggle |
| Derek Riddell - Torquil Travers |
| David Sakurai - Krall |
| Fiona Glascott |
| Wolf Roth - Spielman |
| Victoria Yeates - Bunty |
| Poppy Corby-Tuech - Vinda Rosier |
| Cornell John - Arnold Guzman |
| Callum Forman - Doorman |
| Bernardo Santos - Muggle |
| Sabine Crossen - Mrs. Lestrange |
| Johanna Thea - Ministry of Magic Witch |
| Alexandra Ford - Acolyte |
| Donna Preston - Circus Compare |
| Jag Patel - Senior Wizard |
| Nasir Jama - Macusa Prison |
| Liv Hansen - Ministry of Magic Witch |
| Jason Redshaw - Chef |
| Annarie Boor - Wand Seller |
| Deepak Anand - Wizard |
| Nick Owenford - Circus Wizard |
| Jeremy Oliver - Circus passerby |
| Dave Simon - Muggle at Circus |
| Aykut Hilmi - Shafiq |
| Andrew Blackall - The Rowdy Frenchman |
| Simon Wan - Auror Chang |
| Phil Hodges - Prisoner 001 |
| Stephen McDade - Cirque Arcanus Worker |
| Israel Ruiz - Ministry of Magic Wizard |
| Michael Haydon - Shopkeeper |
| Linda Santiago - Credence's Aunt |
| Sean Gislingham - Muggle |
| Tahir Burhan - Wizard |
| Sean Coleman - Teenager in House |
| Adrian Wheeler - Party Guest |
| Morrison Thomas - Old Carnie |
| Andrew Turner |
| Natalie Lauren - Parisian Woman |
| Alfrun Rose - Red Haired Young Witch |
| Jan Freygang - Wizard |
| Ryan Hannaford - Sailor |
| Connor Wolf - Muggle |
| Maja Bloom - Carrow |
| Andy Summers - New Yorker |
| Olwen Fouéré - Melusine |
| Simon Meacock - Krafft |
| David Wilmot - Portkey Trout |
| Ed Gaughan - French Policeman |
| Jamie Campbell Bower - Young Grindelwald |
| Toby Regbo - Young Dumbledore |
| Hugh Quarshie - Mustafa Kama |
| Isaura Barbé-Brown - Laurena Kama |
| Keith Chanter - Corvus Lestrange Senior |
| Tristan Mamasakhlisashvili - Alf Choo |
