Ben Stiller
- Larry Daley |
Amy Adams
- Amelia Earhart |
Owen Wilson
- Jedediah Smith |
Hank Azaria
- Kahmunrah / The Thinker / Abe Lincoln |
Robin Williams
- Theodore Roosevelt |
Christopher Guest
- Ivan the Terrible |
Alain Chabat
- Napoleon Bonaparte |
Steve Coogan
- Octavius |
Ricky Gervais
- Dr. McPhee |
Bill Hader
- General George Armstrong Custer |
Jon Bernthal
- Al Capone |
Patrick Gallagher
- Attila the Hun |
Jake Cherry
- Nicky Daley |
Rami Malek
- Ahkmenrah |
Mizuo Peck
- Sacajawea |
Kerry van der Griend
- Neanderthal #1 |
Matthew Harrison
- Neanderthal #2 |
Rick Dobran
- Neanderthal #3 |
Randy Lee
- Hun #1 |
Darryl Quon
- Hun #2 |
Gerald Wong
- Hun #3 |
Paul Chih-Ping Cheng
- Hun #4 |
Jay Baruchel
- Joey Motorola |
Mindy Kaling
- Docent |
Keith Powell
- Tuskegee Airman #1 |
Craig Robinson
- Tuskegee Airman #2 |
Samuel Patrick Chu
- Teenage Boy #1 |
Augustus Oicle
- Teenage Boy #2 |
Kai James
- Teenage Boy #3 |
Clint Howard
- Air and Space Mission Control Tech #1 |
Matty Finochio
- Air and Space Mission Control Tech #2 |
George Foreman
- Himself |
Josh Byer
- Capone Gangster #1 |
Sophie Levy
- Young Girl #1 |
Tess Levy
- Young Girl #2 |
Christina Schild
- 'American Gothic' Woman |
Robert Thurston
- 'American Gothic' Farmer |
Alberta Mayne
- Kissing Nurse |
Clifton MaCabe Murray
- Kissing Sailor |
Caroll Spinney
- Oscar the Grouch (voice) |
Thomas Morley
- Darth Vader |
Dan Joffre
- Town Car Driver |
Dave Hospes
- Astronaut |
Regina Taufen
- New York Reporter |
Shawn Levy
- Infomercial Father |
Joe Jonas
- Cherub #1 (voice) |
Kevin Jonas
- Cherub #2 (voice) |
Nick Jonas
- Cherub #3 (voice) |
Eugene Levy
- Albert Einstein Bobbleheads (voice) |
Brad Garrett
- Easter Island Head (voice) |
Ed Helms
- Larry Daley's Assistant (uncredited) |
Jonah Hill
- Brundon (uncredited) |
Ben Garant
- Orville Wright (uncredited) |
Thomas Lennon
- Wilbur Wright (uncredited) |
Dan Savoie
- NY Museum Patron (uncredited) |
Frankie Jonas
- Extra - Child in Museum (uncredited) |
Don Abernathy
- Airport Traveler (uncredited) |
Dennis Albanese
- Foreman (uncredited) |
Aaron Atkins
- Caveman (uncredited) |
Tipper Burton
- Museum Visitor (uncredited) |
Hélène Cardona
- Reporter (voice) (uncredited) |
Lauren Emily Jacobs
- School Girl (uncredited) |
Waléra Kanischtscheff
- Ivan the Terrible (voice) (uncredited) |
Tom MacNeill
- US Marine (uncredited) |
Dan Martino
- U.S. Solider (uncredited) |
Douglas Nelson
- Streltsy (uncredited) |
Kennith Overbey
- Tuskegee Airman (uncredited) |
Robert Underwood
- Air and Space Mission Control Tech (uncredited) |
Crystal the Monkey
- Dexter/Able (uncredited) |